Tuesday, March 18, 2025
The Westin
Los Angeles, California
The Long-Acting Extended Release Antiretroviral Research Resource Program (LEAP) virtually convened clinicians, investigators, developers, community advocacy groups, not-for-profit institutions and regulatory authorities. Attendees shared their diverse perspectives and discussed updates, challenges and future directions in the development of LA formulations. The meeting served as a forum to collectively advance the long-acting field. The Workshop consisted of four Plenary Sessions and four Focus Groups. Below, you’ll find links to video recordings and text summaries of the Plenary and Focus Group presentations.
• View PDF of the full workshop proceedings
SESSION 1 – Public Health and Medical Imperative forLong-Acting HBV Treatments
Chair: Norah Terrault
Funmi Lesi, World Health Organization
Global Public Health Significance
[Presentation] - already in progress
Chari Cohen, Hepatitis B Foundation
Target Product Profile - Perspective of Persons Living with Hepatitis B
[Presentation]
Jordan Feld, Toronto General Hospital Research Institute
Target Product Profile - Medical Perspective
[Presentation]
Paul Domanico, Clinton Health Access Initiative
Market Forecast
[Presentation]
SESSION 2 – Existing Preclinical Work
Chair: Andrew Owen
Arnab K. Chatterjee, PhD, Calibr-Skaggs Institute for Innovative Medicines
ETV Prodrug for LAI
[Presentation]
Marc Baum, Oak Crest Institute of Science
TAF & Other Implants
[Presentation]
Benson Edagwa, University of Nebraska Medical Center
TVF Prodrugs
[Presentation] - already in progress
Rodney Ho, University of Washington
TVF-Based Treatments
[Presentation]
SESSION 3 – Overcoming Roadblocks to Development
Chair: Veronica Miller
Dave Thomas, Johns Hopkins University (for Poonam Mishra, U.S. Food and Drug Administration)
Regulatory Pathways and Issues
[Presentation]
Mila Maistat, Medicines Patent Pool
Low-and Middle-Income Access
[Presentation]
Charles Flexner, Johns Hopkins University
Lessons from HIV Drug Development
[Presentation]