Long-acting ART for children is a deferred priority despite achievable dosing


Optimal doses of long-acting injectable antiretrovirals cabotegravir and rilpivirine were predicted for different weight bands in children and adolescents.

Long-acting injectable antiretrovirals could be future alternatives to oral formulations and might help to address adherence. There is great interest in the potential use of these formulations in the treatment of paediatric HIV.

Clinical trials of new drugs in children and adolescents are delayed by both ethical and logistical barriers complicating the identification of appropriate doses. Physiologically-based pharmacokinetic (PK) modelling can inform dose finding before clinical trials are conducted.