DEVELOPMENT OF PRODRUG APPROACHES FOR LONG-ACTING NANOFORMULATIONS OF EMTRICITABINE-BASED REGIMENS
Grant Source:
NIH/NIAID: 1F31AI129549-01A1; Amer Al-Khouja; 05/01/17 - 04/30/19
Health Topics:
Currently Funded Grants
SYSTEMIC SUSTAINED RELEASE DELIVERY OF ANTIRETROVIRAL AGENTS FOR HIV PREVENTION
Grant Source:
NIH/NIAID: 5R01AI120748-02; Marc Michael Baum (PI); 06/26/15 - 05/31/20
Health Topics:
Development of Ultra Long-Acting Oral HIV Therapies
Grant Source:
NIH/NIAID: 1R01AI131416-01; Andrew Martin Bellinger (PI); 03/22/17 - 02/28/22
Health Topics:
PREVENTION OF HIV ACQUISITION BY LONG-ACTING ANTIRETROVIRAL PREP
Grant Source:
NIH/NIAID: 4R01AI073146-09; Victor J. Garcia-Martinez (PI); 01/05/02 - 07/31/17
Health Topics:
Long-Acting Antiretroviral Nanoparticles for HIV Prophylaxis
Grant Source:
NIH/NIAID: 5R01AI117740-03; Christopher J. Destache (PI); 02/04/16 - 01/31/18
Health Topics:
DEVELOPMENT AND PRE-CLINICAL EVALUATION OF A NOVEL POLYMER-BASED IN-SITU FORMING IMPLANT (ISFI) FOR LONG-ACTING HIV PREP
Grant Source:
NIH/NIAD; 1R01AI131430-01; Soumya Rahima Benhabbour (PI); 03/06/17 - 02/29/20
Health Topics:
Development of Sustained-Release Anti-HIV Nucleoside Phosphonate Nanoparticles
Grant Source:
In this application, researchers propose to utilize novel synthetic chemistry to develop a series of aliphatic tenofovir prodrugs designed to greatly enhance cellular uptake and to provide prolonged intracellular exposure to molecules with potent antiviral activity. They will further extend systemic exposure to these compounds by delivering them in slow-release nanoparticle formulations. They believe that with this “dual-modulation” of drug presentation we will provide systemic exposure to therapeutic concentrations of highly active antiviral compounds for periods of at least four weeks following intramuscular injection.
Health Topics:
PREPARING FOR IMPLEMENTATION OF SUSTAINED RELEASE ANTIVIRALS FOR HIV PREVENTION
Grant Source:
NIH/NIMH; 5R01MH106380-02; Sarit A. Golub (PI); 01/16/15 - 11/30/19
Health Topics:
PREVENTION OF HIV ACQUISITION BY LONG-ACTING ANTIRETROVIRAL PREP
Grant Source:
NIH/NIAID; 4R01AI073146-09: Victor J. Garcia-Martinez (PI); 05/01/07 - 07/31/17
Health Topics:
Sustained Long Acting Prevention Against HIV Program Operation
Grant Source:
NIH/NIAID; 5UM1AI120184-02; Thomas Hope (PI); 07/07/15 - 06/30/20
Health Topics: