Tuberculosis

Long-acting injectables for tuberculosis prophylaxis and treatment: is now the time?

Date: 
8/17/18
Citation: 

Dooley KE. Long-acting injectables for tuberculosis prophylaxis and treatment: is now the time? Int J Tuberc Lung Dis. 2018 Aug 1;22(8):833-34. DOI: https://doi.org/10.5588/ijtld.18.0411.

Tuberculosis (TB) is a wily and enduring foe, responsible for 1 billion deaths in the last 200 years. With the introduction of antibiotics active against Mycobacterium tuberculosis in the 1950s, TB disease could finally be cured with multidrug therapy. TB drugs must still be given for months, generally via directly observed therapy, which is intrusive, expensive, and inconvenient.

Health Topics: 

Long-acting formulations for the treatment of latent tuberculous infection: opportunities and challenges

Date: 
2/15/18
Citation: 

Swindells S, Siccardi M, Barrett SE, et al. Long-acting formulations for the treatment of latent tuberculous infection: opportunities and challenges. Int J Tuberc Lung Dis. 2018 Feb 1; 22(2): 125–132. PMID: 29506608; PMCID: PMC6103451.

Long-acting/extended-release drug formulations have proved very successful in diverse areas of medicine, including contraception, psychiatry and, most recently, human immunodeficiency virus (HIV) disease. Though challenging, application of this technology to anti-tuberculosis treatment could have substantial impact. 

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